Alzheimer's and diabetes share many genetic and molecular links, including glycation.

Alzheimer's, a neurodegenerative disease characterized by progressive, late-onset cognitive decline, and type 2 diabetes, a metabolic disorder appearing at an increasingly younger age and characterized by high glucose levels leading to numerous complications, notably cardiovascular, do not a priori appear to have any particular molecular links.

However, numerous epidemiological data show an increased risk of developing Alzheimer's disease in people with diabetes.

A growing number of studies show that Alzheimer's and type 2 diabetes share many common points, notably at the genetic and molecular levels (1). The underlying mechanisms by which diabetes encourages the initiation and progression of Alzheimer's involve, in particular, inflammation, oxidative stress and glycation.

These observations suggest a promising therapeutic strategy against Alzheimer's disease: the use of drug therapies and hygienic-dietary measures to balance diabetes could serve as a guide for designing treatments for the management of Alzheimer's disease.

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(1): CASTILLO-VELÁZQUEZ, Ricardo, MARTÍNEZ-MORALES, Flavio, CASTAÑEDA-DELGADO, Julio E., et al. Bioinformatic prediction of the molecular links between Alzheimer’s disease and diabetes mellitus. PeerJ, 2023, vol. 11, p. e14738.

https://doi.org/10.7717/peerj.14738