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Sleep, glycation, aging: dangerous links.

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Sleep disorders are a major risk factor for accelerated aging and age-related diseases.


Disorders of the circadian rhythm of sleep arise from the desynchronization between the dark-light and the wake-sleep cycles. This results in sleep disorders: insomnia daytime sleepiness.


The consequences can be terrible: the risk of obesity is multiplied by 2 for each hour of sleep lost and in just a few days, sleep restriction increases insulin resistance, thus promoting metabolic syndrome (1).


New studies confirm that high glycation levels are significantly associated with sleep disorders (2).


The non-respect of the biological clock regulating sleep is therefore at the heart of the risks of increasing age-related diseases (diabetes, cardiovascular diseases...) and accelerated aging.


Logically, a good quality of sleep, at least 7 uninterrupted hours per night, helps to slow down glycation and break the cycle of accelerated aging (3).


© AGE Breaker updated 06 2024


[Glycation is one of the major causes of aging. Resulting from the fixation of sugars on the proteins constituting the organism, glycation generates toxic compounds that cause cellular aging. Glycation is particularly involved in metabolic disorders, skin aging and cognitive decline.]


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(1): GUYON, A. et SPIEGEL, K. Short sleep and obesity risk. Obésité, 2015, vol. 10, p. 51-59.


Doi 10.1007/s11690-014-0415-z


(2): KONISHI, Sakae, HATAKEYAMA, Shingo, IMAI, Atsushi, et al. Effect of advanced glycation end products on nocturia or sleep disorders: A longitudinal study. BJUI compass, 2022, vol. 3, no 2, p. 162-168. Doi.org/10.1002/bco2.114 


(3): ISAMI, Fumiyuki, WEST, Brett J., NAKAJIMA, Sanae, et al. Association of advanced glycation end products, evaluated by skin autofluorescence, with lifestyle habits in a general Japanese population. Journal of International Medical Research, 2018, vol. 46, no 3, p. 1043-1051. Doi.org/10.1177/0300060517736914

 

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